Bone metastasis healing research and support notes reflecting Abbey's personal choices. A summary of information I've been asked to share relates to my personal choices for healing and protecting my bones since 2017.

When first diagnosed with extensive bone mets, I took Zoladex injections, Radiation to one vertebra, IV vitamin C and Liposomal Curcumin (which modulates the RANK/RANKL pathway important to cancer in bone healing beautifully) and Vitamin C and went on a keto for cancer diet.  I started off with taking the calcium the oncologist nurse told me about, but after speaking to a family friend who had had prostate cancer that went to his bones, I switched to the AlgaeCal products.
I used Algae Cal in 2017-18 for about 12 months. Recently, other group members have found that it is similar to the Algae Cal bone restore mix from iherb. Vitamin D and K2 have been used daily since 2017.

Vitamin D is important for regulating calcium and phosphorus levels in the blood, two factors that are extremely important for maintaining healthy bones. Ideally we need to get out in the sunlight in the day time in the UVB light to support healing our bones with Vitamin D from the correct source. Not so long as you burn but at least long enough to get the Vit D's we need. I used to take a combo capsule, and nowadays, I take the D3 in the morning and the K2 with dinner. I read that this was a better way to take them in a protocol shared in the group's Vit D3 study support thread. (under V for Vitamin here). I get myself out in the sun these days a lot more too.

I take this magnesium , zinc, and this liposomal Vitamin C  when I feel like I need. My diet has been excellent but some days I give it some extra suport.

Melatonin
Melatonin helps regulate the balance between bone formation and resorption, which is crucial for maintaining bone health, particularly in postmenopausal women who are at higher risk for osteoporosis due to decreased estrogen levels.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585202/

Melatonin at Pharmacologic Doses Increases Bone Mass by Suppressing Resorption Through Down‐Regulation of the RANKL‐Mediated Osteoclast Formation and Activation https://academic.oup.com/jbmr/article-abstract/17/7/1219/7592093

Melatonin influences bone metabolism by stimulating bone growth and inhibiting osteoclast activity. Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice. www.sciencedirect.com/science/article/abs/pii/S0065128120300957

Data indicates that melatonin improves bone mass by inhibiting the expression of cancer-derived osteolytic factors and by promoting apoptosis in mature osteoclasts. cancerres.aacrjournals.org/content/79/13_Supplement/1970

Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.27090

Buying: purebulk.com/melatonin (also may be available on iHerb for some countries)

Liposomal Curcumin
A major player in my protocol. 

Black Seed Oil (Nigella Sativa)
Thymoquinone, the active ingredient in Nigella Sativa, Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signalling Axis. Bone metastasis was found to be significantly suppressed in the TQ-treated group. www.ncbi.nlm.nih.gov/pmc/articles/PMC6288203/

Buying: MCS Formulas Black Seed Oil Capsules I am taking two caps, 1-2 x day.

Liposomal Baicalein 
Bone-protective and anti-tumor effect of baicalin in osteotropic breast cancer via induction of apoptosis link.springer.com/article/10.1007/s10549-020-05904-y
Baicalin Ameliorates Bone Cancer Pain by Suppressing TRPV1 in Rat Dorsal Root Ganglia journals.sagepub.com/doi/full/10.1177/1934578X19899562
Buying: I love this stuff! Not sure why. It might be all the reading I have done.
Did you know Baicalein can modulate the following signalling pathways in our favor: PI3K/AKT/mTOR, Wnt/β-catenin, MAPK, NF-κB, Notch, ROS, and Shh signalling and 12-Lipoxygenase? I use MCS Formulas Liposomal Baicalein, and MCS formulas ship worldwide.
(Use the coupon code abbey5 at the checkout for 5% off your MCS order)
I take 200mg,  1- 2 x day.

Grape seed extract
Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation pubmed.ncbi.nlm.nih.gov/31625993/
Targeting abnormal bone metabolism to alleviate bone metastasis of breast cancer. pubmed.ncbi.nlm.nih.gov/31625993/
Buying: MCS Formulas Grape Seed Extract

Andrographis.
A potent inhibitor of breast cancer-induced bone metastasis inhibiting RANKL-induced NF-κB and ERK signalling link.springer.com/article/10.1007%2Fs10549-014-2844-7e. I sometimes take 500mg caps (whole root not extract) and takes 1 x daily with food.
Buying: Abbey bought tincture for a while, and then later powder in bulk from a local herbalist and made up capsules and drank  powder just stirred as is in water.

Omega-3 Fatty Acids
Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study www.ncbi.nlm.nih.gov/pmc/articles/PMC7765404/
Fish oil prevents breast cancer cell metastasis to bone.
www.sciencedirect.com/science/article/abs/pii/S0006291X10019418

Buying: I have taken 1-2 of this this fish oil at night . I take at same time with Magnesium powder, Liposomal Vitamin C and my nightly Melatonin.  For a long time added a 100mg mini Aspirin to this nightly, but has stopped the Aspirin of late. Aspirin was being taken with fish oil as a pro-resolving mediator to address any low level inflammation created by dormant cancer cells and because it might help with bone remodelling.
California Gold Nutrition DHA Pharmaceutical Grade Fish Oil is very cheap yet features KD-PÜR® IFOS™ 5-Star rated high quality fish oil concentrate processed in Germany and is specifically designed for individuals looking for an ultra-concentrated, once-daily softgel. Per dose, DHA 700 offers the highest quality fish oil, with no less than 70% DHA, at the best overall value. Vegan options are out there. such as an algae based Omega-3 from Free Spirit in Australia. It’s not cheap but I prefer it and tend to mix things up; half fish, half algae.

Solomon's Seal
Solomon's Seal was recommended to me by Dr. McKinney : tincture works to strengthen the entire muscular-skeletal system. I have one bottle in my supplement basket and one in the bathroom, which I will apply topically after a shower before bed when I feel any little aches or pains. Works so well! www.cortesiaherbalproducts.com/wp-content/uploads/2018/07/therapeutic-qualities-of-solomon%E2%80%99s-seal.pdf
Great Product: https://www.cortesiaherbalproducts.com/product/cortesia-solomons-seal/?attribute_choose-option=2oz. They do ship internationally.

Dr. Neil McKinney recently recommended this one in one of his presentations from Harmonic Arts  (Canada and US shipping only). This appears to be the only Solomon's Seal that is made using whole plants and I have been using it internally and as a rub and find it to be effective. This one.
Research:
Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. Conclusion: This experiment demonstrates that the administration of PSP to ovariectomized rats reverses bone loss and prevents osteoporosis. pubmed.ncbi.nlm.nih.gov/21550389/

Polygonatum sibiricum polysaccharide attenuates bone marrow-derived macrophages to differentiate into osteoclasts and protects against lipopolysaccharide-induced osteolysis in vivo. www.cjter.com/EN/Y2017/V21/I20/3117

Insulin-like Growth Factor-1
IGF Axis note: Preclinical evidence suggests that tumour cells can be primed to metastasize to the bone by a high IGF-1 environment in the primary tumour, suggesting that bone metastases may reflect IGF dependency.aacrjournals.org/clincancerres/article/25/12/3479/81435/Bad-to-the-Bone-The-Role-of-the-Insulin-Like Insulin-like Growth Factor-1 (IGF-1) is a nutrient-responsive growth factor that activates MAPK and PI3K/AKT signalling which are critical drivers of tumour growth. Preclinical evidence shows that IGF-1 and IGF-1R are the main factors associated with breast cancer bone metastasis.
aacrjournals.org/.../Bone-Derived-IGF-Mediates... IGF-1 pathway inhibitors: Diet No Sugar, No Dairy, Longer fasts, Metformin, R-Alpha Lipoic Acid (no 'S' )Tamoxifen Vitamin D3, Curcumin , Genistein, Apigenin, Quercetin www.ncbi.nlm.nih.gov/pmc/articles/PMC6721736/

Bone Loss from AIs Directly Contributes to Bone Mets https://www.oncotarget.com/article/14139/text/ A weak bone matrix sets up the perfect environment for bone mets.  There are ways to reduce bone loss while on AIs or in menopause in general, whether this be through pharmacological options or supplements plus exercise or both.

DON'T FORGET Stretching, moving, and weight bearing are all important to support healthy bones. I do Qi Gong asmy exercise which is mostly stretching. I use the Zen Chi machine for 10 minutes in the morning and at night.  The 10 minutes on the Zen Chi Machine encourages the flow of synovial fluid between the discs. This helps to reduce inflammation and ease pain by supplying nutrients and oxygen to the tissues, and also by helping to expel the toxins that arise from inflammation."  I do light weights with my stretches these days and carry my 2.7kg dog around in my arms too much!

Vitamin C is super important to me.
Liposomal Vitamin C is so important for building the collagen matrix that our bones are made of. The fascia that wraps and protects each organ is made from a matrix of collagen also, making Vitamin C super important factor to inhibiting metastasis in general. I’ve been making and taking loads of Liposomal Vitamin C from very early on and my bones just soaked it up in huge quantities the first couple of years. These days I still have a good tablespoon as maintenance daily and more when needed. “..maintaining the collagen triple helix structure of the fold to enhance its strength and stability is the main function that Vitamin C serves to influence collagen. For example, Vitamin C has been proved that can inhibit the degradation and re-modeling of ECM and can prevent bone metastasis of cancer cells..” www.sciencedirect.com/science/article/pii/S0753332220307812

Structured water
The role of calcium (Ca²⁺) in cancer cell proliferation, migration, and invasion has been well established. Interestingly, emerging evidence indicates that Ca²⁺ signalling played a key role in bone metastasis, for it not only promotes cancer progression but also mediates osteoclasts and osteoblasts differentiation. Therefore, Ca²⁺ signalling has emerged as a novel therapeutical target for cancer bone metastasis treatments" 
https://pubmed.ncbi.nlm.nih.gov/36071984/

"Mineralised bone is a kind of electric battery composed from nano-metric cells formed from negatively charged nano-crystallites embedded into positively charged inter-crystallite water. The cells are strongly charged in a newborn bone and discharge with age. The charge dissipation is due to the counter Ca²⁺ and OH⁻ ionic currents. Relationships between the spatiotemporal and charge regulation processes and their effect on the mechanical properties of bone are discussed in detail in this article.
The peculiarities of charge distribution and spatiotemporal changes in electronic and atomic structure of bone tissue https://pubs.rsc.org/en/content/articlelanding/2022/ta/d2ta02340g/

I have been drinking magnetically structured water daily since 2018. We have the MEA Water  Iris device on our cold water pipe under kitchen floor. From an amazing scientist who is Australian supplier who ships his devices worldwide. The more I learn about water, bones and energy I'm sure drinking great water and taking loads of liposomal Vitamin C to support collagen creation has probably played a synergistic role in my healing. We have been given a 10% discount across  all the MEA devices with the code MHC10