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Ashwagandha targets cancer stem cell signalling pathways and may enhance standard of care

Don't overlook the power of ancient botanical medicines when creating a powerful cancer healing protocol

Ashwagandha Cancer Research Summary
The ancient botanical Ashwagandha Withania somnifera (also called “Indian Ginseng”) targets cancer stem cell signalling pathways. See links to research below. 
Ashwagandha may also supports cancer patients during a Ferroptosis protocol and research below indicates Ashwagandha to be synergistic with Paclitaxel, Cisplatin, 5-FU, Doxorubicin & Radiotherapy.

Cancer Stem Cell Pathways

wnt A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms Link to Research
NF-κB Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ Link to Research
Notch Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells Link to Research
Hedgehog Hedgehog inhibitors from Withania somnifera Link to Research
JAK-STAT Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells Link to Research
PI3K/Akt/ mTOR Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E Link to Research
TGF/SMAD Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling Link to Research

Ferroptosis, Chemotherapy & Radiation Synergies

Ferroptosis Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis Link to Research
Paclitaxel Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Link to Research
Cisplatin Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells Link to Research
5-FU Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells Link to Research
Doxorubicin Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancer Link to Research
Radiotherapy Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition Link to Research

Ashwagandha and Breast Cancer Research

maybe not what you expected.

Ashwagandha research article from 2021
Keeping abreast about Ashwagandha in breast cancer

Various forms of Withania somnifera were used and several in vitro, in vivo, and clinical studies were reported by researchers. They found Ashwagandha to exhibit anti-apoptotic, anti-metastatic, anti-invasive and anti-inflammatory properties and gave the evidence that Ashwagandha has a capability for averting and treating breast cancer.

Various in vitro and in vivo studies suggested Ashwagandha may possess a potential for treating breast cancer, especially ER/PR positive breast cancer and triple-negative breast cancer. A clinical trial has also been conducted in the past that suggested its potential in refining quality of life in breast cancer patients. Studies directed towards molecular pathways have helped in unravelling the key mechanisms of Ashwagandha."

Read the ScienceDirect article.

MCS Formulas have pure organic Ashwagandha in 400mg capsules. Learn more at MCS Formulas.

DISCLAIMER: Any and all information in this post was gathered from published research in cell lines or animals, or from typical clinical use. It may not be complete, may not have not been verified in humans, and is NOT meant or given as medical advice, but only as a guide to further exploration.

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