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Apigenin targets cancer stem cell pathways and enhances standard of care treatments

Don't overlook the new bioavailable form of apigenin

 Liposomal Apigenin formula designed to match therapeutic dosages.

When I was targeting cancer stem cell and blocking all the pathways I could with everything I could get my hands on back in 2018-19 I was drinking loads of organic chamomile tea and parsley tea and a liposomal apigenin supplement just simply did not exist.

Dried parsley has been reported to have the maximum quantity of apigenin, at 45,035 μg/g. Additional sources of Apigenin are dried flower of chamomile, containing 3,000 to 5,000 μg/g; celery seeds, containing 786.5 μg/g; and vine spinach and Chinese celery, containing 622 μg/g and 240.2 μg/g. I'm still drinking my chamomile tea and eating parsley out of the garden daily AND I am super grateful that MCS formulas has created a Liposomal Apigenin which contains a whopping 150 mg Apigenin, extracted from Grapefruit Peel and encapsulated in liposomes to ensure it reaches the cells. It just makes dosing easy.

Dosing notes: 1 x 150 mg liposomal delivered dose, could reach the 1–5μmol/L blood concentration required for action.

If concerned about a potential accumulation, we can also consider taking a weekend break from the capsules.

Toxicity research and liver protection induced by Apigenin

It looks like there is one study out there suggesting high dose Apigenin might  be toxic to the liver. The study was done using IV Apigenin on mice and it's the only one, where as there are are several examples of research pointing to  Apigenin being protective against liver injury. Here are a few:

So, overall, the literature reports in favour of liver protection induced by Apigenin and not toxicity. Furthermore, a review on Apigenin referring to doses used in animals even higher, with no toxicity on the exposed areas is here Based on the literature referenced above:

How does Apigenin support cancer patients during and after treatments?

We have all heard the sad news that chemotherapy and radiation can not target the cancer stem cells and when I write this in 2023 from Australia I am left to figure the stem cell part on my own or increase my chances of facing a reoccurrence and the offer to take up the next line of even harsher treatment  (if there is one). Cancer stem cells are not something my standard of care oncologist is likely to discuss, let alone address. Perhaps if I lived in another country, had a great job with great insurance I could pay an integrative oncologist or naturopathic oncologist to work this out with me. I  but I don't, so for me it's a matter of listing down all the inter-signalling pathways that cancer stem cells rely on for activity, plus some common kill strategies, and then searching for the name of that pathway or strategy and the compound I'm learning about; in this case it's Apigenin. The below list are the ones from my list  that I  found cancer research on using Apigenin in relationship to cancer stem cell pathways, hypoxia, chemotherapy, radiation and ferroptosis. I'm currently in my 5th year of stage 4 remission myself, and am taking 1 x 150mg MCS formulas Liposomal Apigenin daily before lunch. My elderly MIL with advanced dementia is now taking the same dose as me and it is amazing to witness the power of Apigenin on her mental health.  After only 3 days her chronic anxiety was greatly alleviated. You can read more on Apigenin here

Apigenin Cancer Stem Cell and Treatment Support Research
wnt Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs
NF-κB Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
JAK-STAT Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells
PI3K/Akt/ mTOR Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention
TGF/SMAD Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism
Ferroptosis Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms
Hypoxia Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
Paclitaxel Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer
Cisplatin Apigenin enhances the cisplatin cytotoxic effect through p53 modulated apoptosis
5-FU 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma
Doxorubicin Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
Radiotherapy Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis
Immunotherapy Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells

DISCLAIMER: Any and all information in this post was gathered from published research in cell lines or animals, or from typical clinical use. It may not be complete, may not have not been verified in humans, and is NOT meant or given as medical advice, but only as a guide to further exploration.

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