Apigenin targets cancer stem cell pathways and enhances standard of care treatments
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Apigenin targets cancer stem cell pathways and enhances standard of care treatmentsDon't overlook the new bioavailable form of apigenin
Liposomal Apigenin formula designed to match therapeutic dosages.
When I was targeting cancer stem cell and blocking all the pathways I could with everything I could get my hands on back in 2018-19 I was drinking loads of organic chamomile tea and parsley tea and a liposomal apigenin supplement just simply did not exist.
Dried parsley has been reported to have the maximum quantity of apigenin, at 45,035 μg/g. Additional sources of Apigenin are dried flower of chamomile, containing 3,000 to 5,000 μg/g; celery seeds, containing 786.5 μg/g; and vine spinach and Chinese celery, containing 622 μg/g and 240.2 μg/g. I'm still drinking my chamomile tea and eating parsley out of the garden daily AND I am super grateful that MCS formulas has created a Liposomal Apigenin which contains a whopping 150 mg Apigenin, extracted from Grapefruit Peel and encapsulated in liposomes to ensure it reaches the cells. It just makes dosing easy.
Dosing notes: 1 x 150 mg liposomal delivered dose, could reach the 1–5μmol/L blood concentration required for action.
If concerned about a potential accumulation, we can also consider taking a weekend break from the capsules. www.ncbi.nlm.nih.gov/pmc/articles/PMC8167032/
Toxicity research and liver protection induced by Apigenin
It looks like there is one study out there suggesting high dose Apigenin might be toxic to the liver. The study was done using IV Apigenin on mice and it's the only one, where as there are are several examples of research pointing to Apigenin being protective against liver injury. Here are a few:
- Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model
- Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
- Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity
- Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
So, overall, the literature reports in favour of liver protection induced by Apigenin and not toxicity. Furthermore, a review on Apigenin referring to doses used in animals even higher, with no toxicity on the exposed areas is here Based on the literature referenced above:
- Apigenin is helpful to the liver.
- The dose of Apigenin in one 200mg capsule of MCS Formulas Liposomal Apigenin provides an Apigenin blood level below the dose reported by the one acute IV Apigenin mouse study that points to potentially presenting toxicity
How does Apigenin support cancer patients during and after treatments?
We have all heard the sad news that chemotherapy and radiation can not target the cancer stem cells and when I write this in 2023 from Australia I am left to figure the stem cell part on my own or increase my chances of facing a reoccurrence and the offer to take up the next line of even harsher treatment (if there is one). Cancer stem cells are not something my standard of care oncologist is likely to discuss, let alone address. Perhaps if I lived in another country, had a great job with great insurance I could pay an integrative oncologist or naturopathic oncologist to work this out with me. I but I don't, so for me it's a matter of listing down all the inter-signalling pathways that cancer stem cells rely on for activity, plus some common kill strategies, and then searching for the name of that pathway or strategy and the compound I'm learning about; in this case it's Apigenin. The below list are the ones from my list that I found cancer research on using Apigenin in relationship to cancer stem cell pathways, hypoxia, chemotherapy, radiation and ferroptosis. I'm currently in my 5th year of stage 4 remission myself, and am taking 1 x 150mg MCS formulas Liposomal Apigenin daily before lunch. My elderly MIL with advanced dementia is now taking the same dose as me and it is amazing to witness the power of Apigenin on her mental health. After only 3 days her chronic anxiety was greatly alleviated. You can read more on Apigenin here
DISCLAIMER: Any and all information in this post was gathered from published research in cell lines or animals, or from typical clinical use. It may not be complete, may not have not been verified in humans, and is NOT meant or given as medical advice, but only as a guide to further exploration.