The Power of Liposomes: How Cancer Patients Can Increase Supplement and Drug Efficacy Naturally
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Liposomes and Cancer Treatment: A Promising Approach for Enhancing Bioavailability and Reducing Interactions
Liposomal formulas are becoming increasingly popular in the world of medicine and healthcare. They offer a unique way to deliver nutrients, medications, and supplements directly into the bloodstream, bypassing the liver's first-pass metabolism. This allows for increased bioavailability and better absorption rates than traditional delivery methods.
Liposomal Formulas Enhance Bioavailability
The liposome structure is made up of phospholipids, which are similar in composition to cell membranes in our bodies. This allows for easier integration into our cells, leading to a higher absorption rate and longer circulating time in the blood stream.
Additionally, liposomes can be neutrally charged or positively charged depending on their formulation. Neutrally charged liposomes have been shown to have longer circulation time in the blood stream than positively charged ones.
This increased bio-availability also makes it possible for lower doses of drugs or supplements to be effective since there is less wastage as compared with traditional methods. Enhanced bioavailability through liposomal formulas has opened new doors when it comes to cancer treatment by ensuring maximum drug and supplement efficacy while minimising side effects caused by other delivery methods such as chemotherapy.
Phospholipids Enhanced with Chitosan
Phospholipids with chitosan have gained significant attention in the development of liposomal formulas. Combining these ingredients enhances the bioavailability of various active compounds, including those used for cancer treatment.
Combining phospholipids with Chitosan can create neutrally charged liposomes capable of bypassing liver phase 1 metabolism. This means that more active compound will reach their intended targets instead of being metabolized or excreted before reaching their full potential. Utilizing these natural ingredients together provides an opportunity to enhance supplement and drug delivery efficacy.
Liposomes and First-pass Metabolism
First-pass Metabolism also known as Phase 1 of liver metabolism and it is where Cytochrome P450 enzymes; CYP2C9, CYP3A4 and CYP2D6, all highly significant metabolic enzymes perform crucial roles in the metabolism of natural compounds and drugs in the human body.
Cytochrome P450 enzymes; CYP2C9, CYP3A4 and CYP2D6 are extensively involved in the metabolism of oncology drugs. Some examples of such oncology drugs include paclitaxel, docetaxel, imatinib, erlotinib, sorafenib, and sunitinib. These medications are used to treat different types of cancers including breast cancer, lung cancer, leukemia and gastrointestinal stromal tumors (GIST). The importance of understanding the role of cytochrome P450 enzymes in drug therapy cannot be overstated as it influences drug efficacy and toxicity levels in patients undergoing these treatments.
Remember, by utilising Liposomal formulas combining phospholipids and chitosan, your supplements bypass liver phase 1 metabolism and enter the cells directly, increasing absorption rates and fewer clashes with first-pass metabolic enzymes.
It is important to note that while liposomal formulations offer many benefits, speaking with a healthcare professional before starting any new supplement or medication regimen is always recommended.
Many of the best liposomal formulas contain Chitosan. Although Chitosan is generally considered non-allergenic, individuals with a shellfish allergy may still be at risk of an allergic reaction.
These formulas may also affect bile production by the liver, causing further complications for patients with pre-existing liver conditions. As such, healthcare providers must carefully monitor patients using liposomal therapies and adjust dosages as needed based on individual health factors. It's essential for patients to communicate any concerns or changes in symptoms with their medical team promptly so they can receive appropriate care and support throughout their treatment journey.
Directions on the bottle will consider timing (e.g empty stomach is important) and follow practitioner's guidance in regards to the dose that is best for you at any given stage of your cancer healing journey.
MCS formulas is trusted source of neutrally charged liposomal compounds for cancer patients.
Liposome encapsulated, pure, highest potency compounds formulated into dry powder capsules that can be safely shipped worldwide whilst giving back 50% of net profits to the cancer projects overlooked by large pharmaceutical companies due to non-existing intellectual property that is required to convert discoveries in to profitable products. As a privately owned and ethical company, MCS Formulas has the freedom to put patients need first and allocate a major part of its profits to support high-potential academic projects.
Learn more and find our MCS formulas discount code here - www.myhealingcommunity.com/mhc-discounts-with-suppliers/
Lee M. K. (2020). Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches. Pharmaceutics, 12(3), 264. https://doi.org/10.3390/pharmaceutics12030264
Kumari, L., Choudhari, Y., Patel, P., Gupta, G. D., Singh, D., Rosenholm, J. M., Bansal, K. K., & Kurmi, B. D. (2023). Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. Life (Basel, Switzerland), 13(5), 1099. https://doi.org/10.3390/life13051099
Markowski, A., Zaremba-Czogalla, M., Jaromin, A., Olczak, E., Zygmunt, A., Etezadi, H., Boyd, B. J., & Gubernator, J. (2023). Novel Liposomal Formulation of Baicalein for the Treatment of Pancreatic Ductal Adenocarcinoma: Design, Characterization, and Evaluation. Pharmaceutics, 15(1), 179. https://doi.org/10.3390/pharmaceutics15010179
Mahmud, M., Piwoni, A., Filipczak, N., Janicka, M., & Gubernator, J. (2016). Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro. PloS one, 11(12), e0167787. https://doi.org/10.1371/journal.pone.0167787
Duarte, J. A., Gomes, E. R., De Barros, A. L. B., & Leite, E. A. (2023). Co-Encapsulation of Simvastatin and Doxorubicin into pH-Sensitive Liposomes Enhances Antitumoral Activity in Breast Cancer Cell Lines. Pharmaceutics, 15(2), 369. https://doi.org/10.3390/pharmaceutics15020369
Gomes, E. R., Carvalho, A. T., Barbosa, T. C., Ferreira, L. L., Calado, H. D. R., Sabino, A. P., & Oliveira, M. C. (2022). Fusion of Tumor-Derived Exosomes with Long-Circulating and pH-Sensitive Liposomes Loaded with Doxorubicin for the Treatment of Breast Cancer. AAPS PharmSciTech, 23(7), 255. https://doi.org/10.1208/s12249-022-02349-y
DISCLAIMER: Any and all information in this post was gathered from published research in cell lines or animals, or from typical clinical use. It may not be complete, may not have not been verified in humans, and is NOT meant or given as medical advice, but only as a guide to further exploration.