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Hydrogen Looks Set to Transform Cancer Care

Author Credit: The information in this post was originally shared to members of the Healing Cancer Study Support Group in July 2023. Permission to share the information here on MyHealingCommunity.com was granted by the author Dr. Daniel Thomas. See the sharing guidelines for this post above.

In the quest to improve cancer treatment results and boost patient well-being, an unexpected helper has emerged from the world of molecular elements—hydrogen gas. Hydrogen is set to revolutionise cancer care with its exceptional ability to act as a potential therapeutic agent and a promoter of general health. Here's a closer look at the cancer-specific research and its implications for patients and medical professionals.

The Dual Potential of Hydrogen in Cancer Treatment

Molecular Hydrogen's role in cancer treatment is multifaceted, exhibiting a capacity to induce or regulate apoptosis. This process can either lead to the death of harmful cancer cells or protect healthy cells from damage. Interestingly, hydrogen gas has the ability to adjust its role based on the cellular environment—acting as an inhibitor for pro-apoptotic proteins in some instances or as an enhancer of anti-apoptotic mechanisms in others. This dual potential offers a nuanced approach to targeting cancer cells while safeguarding normal ones, highlighting Hydrogen's versatility as a therapeutic agent.

Arresting the Cell Cycle

Research has shown that hydrogen gas can halt the proliferation of cancer cells by arresting their cycle at a critical phase, thereby inhibiting tumour growth. This effect is linked to Hydrogen's ability to regulate various cell cycle-related proteins, including Cyclin D1, CDK4, and CDK6, showing us another intriguing layer of its anti-cancer capabilities.

Immune System Modulation

Controlling malignant tumours' recurrence and spread is challenging due to factors like immuno-senescence and the gradual weakening of the immune system. Tumours can exhaust and deteriorate key immune cells, including T cells and natural killer cells, leading to increased regulatory T cells. Traditional treatments like surgery and chemotherapy can accelerate tumour spread. A 2019 study on 20 non-small cell lung cancer patients showed that two weeks of daily hydrogen inhalation significantly improved immune function, reducing exhausted T cells and increasing NK cells.

In 55 colorectal cancer patients, three months of hydrogen therapy reduced PD-1+ CD8+ T cells, associated with poor prognosis and improved outcomes. Hydrogen gas, combined with the immunotherapy drug Nivolumab, enhanced the effectiveness of exhausted CD8+ T cells in 42 lung cancer patients, leading to significantly longer survival compared to Nivolumab alone.

It also enhanced the effects of radiotherapy and chemotherapy by increasing the apoptosis rate in cancer cells. A case report described a non-small cell lung cancer patient who, after failing conventional treatments, experienced a reduction and eventual disappearance of brain metastases within a year of hydrogen gas treatment. This treatment also stabilised liver and lung metastases, extending survival.

Oxidative Stress and Inflammation Reduction

One of the most profound benefits of molecular Hydrogen is its selective antioxidant activity. Unlike other antioxidants, Hydrogen discriminates between harmful cytotoxic radicals and beneficial reactive oxygen species (ROS), reducing oxidative stress and inflammation without disrupting essential cellular functions. This specificity is particularly valuable in cancer treatment, where maintaining the balance of cellular processes is critical. 

High levels of Reactive Oxygen Species (ROS) play a significant role in the development and progression of cancer, negatively impacting patients undergoing treatments like chemotherapy and radiotherapy. Infections and exposure to fungal pathogens, chemicals, and pollutants exacerbate these levels. Elevated ROS can activate the PI3K/Akt/mTOR pathway, leading to apoptosis in non-cancerous cells and initiating a harmful cycle of toxic effects that may contribute to cancer recurrence and cachexia. In the case of ascites and ovarian cancer cells, increased expression of PGC1α is evident. It plays a significant role in chemoresistance as the process mediates the cells' response to oxidative stress. Hydrogen has been found to play a crucial part in regulating PGC1α expression. 

Hydrogen has shown the potential to counteract the downstream inflammation within the tumour microenvironment and in non-cancer cells impacted by aggressive treatment. It does this by minimising electron leakage in the electron transport chain, preventing the generation of superoxide in mitochondrial complex I, and correcting electron flow. This, in turn, reduces oxidative damage within the mitochondria of healthy cells.

Cancer patients must manage excessive systemic levels of ROS promptly, with guidance from an integrative health professional. Equally important is identifying and addressing the underlying causes and contributors of the excessive ROS with the guidance of a functional, naturopathic, or integrative health practitioner, ensuring a comprehensive approach to treatment and care.

Cancer Signalling Pathways

Hydrogen is emerging as a promising therapeutic agent by modulating cellular signalling pathways. Its influence on specific proteins and RNA, crucial in cancer progression, highlights its potential as part of comprehensive cancer care strategies. RNA sequencing analysis revealed hydrogen-induced TNF/NF-κB and apoptosis pathways in endometrial cancer cells. 

Hydrogen has been shown to reduce STAT3/Bcl2 signalling, promoting cancer cell death and encouraging autophagy. Furthermore, it suppresses the expression of the long non-coding RNA MALAT1 and the transcription factor EZH2, both implicated in the proliferation and migration of gastric cancer cells, further revealing its significant therapeutic promise.

Integrative Approaches to Cancer Therapy

In a comprehensive follow-up study, 82 cancer patients at stages III and IV underwent treatment through hydrogen inhalation, adhering to a "real world evidence" methodology over a period of 3 to 46 months. Remarkably, within the initial four weeks of treatment, participants experienced significant improvements in fatigue, insomnia, anorexia, and pain, indicating a positive response to the therapy. Their overall physical condition saw a notable enhancement of 41.5%, with lung cancer patients showing the most significant improvement, while those with pancreatic and gynecologic cancers experienced the least progress.

In cases where tumour markers were elevated—58 in total—a promising 36.2% displayed a reduction within 13 to 45 days, averaging at 23 days post-inhalation-treatment initiation. This effect was most pronounced in lung cancer patients, with pancreatic and hepatic cancer patients observing the least reduction.

Out of 80 patients with visible tumours on imaging scans, the overall disease control rate post-hydrogen inhalation treatment was 57.5%, including cases of complete and partial remission occurring between 21 and 80 days, with a median of 55 days. The disease control rate was significantly higher in stage III patients compared to those at stage IV.

This study underscores the potential of hydrogen inhalation at 3000ml/min as a therapeutic measure, especially for lung cancer, and opens avenues for further research into tailored treatments for different cancer types.

Benefits

Beyond its direct anti-tumour actions, Hydrogen offers multiple benefits that address the side effects of conventional cancer treatments. From alleviating bone marrow damage to protecting the healthy cells of the gut, brain, kidneys, and liver during chemotherapy, hydrogen therapy supports patient health holistically. Research into its role in enhancing the outcomes of immunotherapy, in particular, emphasises the clear potential of Hydrogen as part of combination therapy regimens of the future.

Administration and Access to 3000 ml/min Hydrogen Machines

The versatility of Hydrogen extends to its administration methods, with drinking Hydrogen-rich water throughout the day being both safe and effective alongside Hydrogen inhalation being accessible and adaptable to various patient needs, including those diagnosed with lung cancer, where inhalation using a machine that produces 3000 ml/min has shown significant promise. At the time of writing this summary, the HAH machines are the only hospital-grade 3000 ml/min machines shipped worldwide directly to patients via FedEx and DHL.

Learn More

To learn more about the author's experience using the HAH-3000, study support group members are welcome to contact the author directly via the Hydrogen thread in the group or send questions directly via this website's contact page. Readers can also learn much about Hydrogen research and hospital-grade Hydrogen machines at the Health and Hydrogen website.

The Path Ahead

The insights gleaned from ongoing research into molecular Hydrogen's role in cancer treatment are heartening. Hydrogen stands out as a potentially powerful tool in oncology because it offers a multifaceted approach that includes selective antioxidant activity, apoptosis regulation, cell cycle arrest, and modulation of cellular pathways.

Its capacity to mitigate the adverse effects of existing treatments while directly combating cancer cells opens the door to more refined and patient-friendly therapeutic strategies. Hydrogen therapy may become a cornerstone of future cancer care, embodying hope for patients worldwide.

Cancer patients and doctors are encouraged to explore this emerging therapeutic field, as hydrogen therapy represents not just a glimpse into the future of cancer care but a tangible, evolving reality with extraordinary potential.

A PDF version of this blog post can be downloaded here

Discount Code for HAH Hydrogen Machines

The author of this summary is in long-term remission from a metastatic breast cancer diagnosis in 2017 and now owns the HAH-3000 machine shown here and uses it daily to inhale hydrogen and drink hydrogen-rich water. An affiliate discount on all HAH machines for the Healing Cancer Study Support Group members requires the code abbey5 to be entered on the HAH website during checkout.

Highest Strength Hydrogen Water Tablets

The highest-strength hydrogen-rich water-producing tablets available are hydrogen tablets, which provide 12ppm. Most provide 8ppm. A reputable online store, Optimoz, has 12ppm tablets; however, they only deliver to Australia and NZ. We are still seeking more retailers and will add them here.

Author Credit: The information in this post was originally shared to members of the Healing Cancer Study Support Group in July 2023. Permission to share the information here on MyHealingCommunity.com was granted by the author Dr. Daniel Thomas. See the sharing guidelines for this post above.

References

Akagi, J., & Baba, H. (2018). Hydrogen gas restores exhausted CD8+ T-cells in patients with advanced colorectal cancer to improve prognosis. Oncology Reports. https://doi.org/10.3892/or.2018.6841

Akagi J, Baba H. Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer. Oncol Lett. 2020;20(5):258. doi:10.3892/ol.2020.12121

Chen, Ji-Bing1,2; Kong, Xiao-Feng1; Qian, Wei1; Mu, Feng1; Lu, Tian-Yu1,2; Lu, You-Yong3; Xu, Ke-Cheng MD1,2,*. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Medical Gas Research 10(4):p 149-154, Oct–Dec 2020. | DOI: 10.4103/2045-9912.304221

Chen J, Mu F, Lu T, Du D, Xu K. Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report. Onco Targets Ther. 2019;12:11145-11151. Published 2019 Dec 17. doi:10.2147/OTT.S235195

Fu Z, Zhang J. Molecular hydrogen is a promising therapeutic agent for pulmonary disease. J Zhejiang Univ Sci B. 2022;23(2):102–122. doi:10.1631/jzus.B2100420

Higashimura Y, Baba Y, Inoue R, et al. Effects of molecular hydrogen-dissolved alkaline electrolysed water on the intestinal environment in mice. Med Gas Res. 2018;8(1):6-11. Published 2018 Apr 18. doi:10.4103/2045-9912.229597

Hirano SI, Aoki Y, Li XK, Ichimaru N, Takahara S, Takefuji Y. Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study. Med Gas Res. 2021;11(3):104-109. doi:10.4103/2045-9912.314329

Izquierdo-Torres, E., Hernández-Oliveras, A., Fuentes-García, G., & Zarain-Herzberg, Á. (2020). Calcium signalling and epigenetics: A key point to understand carcinogenesis. Cell Calcium91, 102285. https://doi.org/10.1016/j.ceca.2020.102285

Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., & Guo, S. (2018). Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer. Molecular Medicine Reports, 18(2), 2182-2190. https://doi.org/10.3892/mmr.2018.9168

Johnsen, H. M., Hiorth, M., & Klaveness, J. (2022). Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes. Molecules28(23), 7785. https://doi.org/10.3390/molecules28237785

Li S, Liao R, Sheng X, Luo X, Zhang X, Wen X, Zhou J, Peng K. Hydrogen Gas in Cancer Treatment. Front Oncol. 2019 Aug 6;9:696. doi: 10.3389/fonc.2019.00696. PMID: 31448225; PMCID: PMC6691140.

Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pac J Cancer Prev. 2023;24(1):37-47. Published 2023 Jan 1. doi:10.31557/APJCP.2023.24.1.37

Rochette L, Dogon G, Zeller M, Cottin Y, Vergely C. Antitumoral Activity of Molecular Hydrogen and Proton in the Treatment of Glioblastoma: An Atypical Pharmacology? Brain Sciences. 2023; 13(8):1168. https://doi.org/10.3390/brainsci13081168

Suliman, M. M. (2022). CD20+ T cells: Phenotype, origin and presence in the tumour microenvironment. https://core.ac.uk/download/544394215.pdf

Yamamoto, H., Ichikawa, Y., Sato, B., Takefuji, Y., & Satoh, F. (2021). Molecular Hydrogen as a Novel AntitumorAntitumor Agent: Possible Mechanisms Underlying Gene Expression. International Journal of Molecular Sciences22(16). https://doi.org/10.3390/ijms22168724

Yang Q, Ji G, Pan R, Zhao Y, Yan P. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Mol Clin Oncol. 2017;7(5):891-896. doi:10.3892/mco.2017.1409

Yao, T., Yang, H., & Li, L. (2019). Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. Molecules24(14). https://doi.org/10.3390/molecules24142627

Zanini, D., Todorovic, N., Korovljev, D., Stajer, V., Ostojic, J., Purac, J., Kojic, D., Vukasinovic, E., Djordjievski, S., Sopic, M., Guzonjic, A., Ninic, A., Erceg, S., & Ostojic, S. M. (2021). The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Experimental Gerontology155, 111574. https://doi.org/10.1016/j.exger.2021.111574

Zhou, P., Lin, B., Wang, P., Pan, T., Wang, S., Chen, W., Cheng, S., & Liu, S. (2018). The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats. Journal of Radiation Research60(1), 17-22. https://doi.org/10.1093/jrr/rry074

Zufayri Mohd Noor, M. N., Alauddin, A. S., Wong, Y. H., Looi, C. Y., Wong, E. H., Madhavan, P., & Yeong, C. H. (2023). A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pacific Journal of Cancer Prevention : APJCP24(1), 37-47. https://doi.org/10.31557/APJCP.2023.24.1.37

Healing Cancer Study Support Facebook Group Members:

Click here to visit the Cancer Study Support Group A-Z list of thread and files. There is a link to the group's Hydrogen thread under H.
Use code abbey5 for 5% off all HAH products

* MCS offers ULTRAFAST WORLDWIDE SHIPPING with FedEx and UPS
** MCS are a SOCIAL ENTERPRISE - see the We Donate 50% program

DISCLAIMER: Any and all information in this post was gathered from published research in cell lines or animals, or from typical clinical use. It may not be complete, may not have not been verified in humans, and is NOT meant or given as medical advice, but only as a guide to further exploration.

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