Treatment Resistance Overview

Overview of treatment-resistance, progression-pattern, and cross-cancer treatment-escape topics

This section gathers cross-cancer treatment-resistance topics in one place.

Use it when the main question is about why treatment may stop working, not just what symptom it causes.

Start here

Treatment Resistance
Cross-cancer resistance mechanisms, progression patterns, pharmacokinetic questions, and treatment-escape logic.
Dormant Cancer Cells
Cross-cancer guide to dormancy, residual disease, reactivation risk, and treatment strategy questions.
Senescence — The Second Escape Route
Hub for therapy-induced senescence, SASP biology, senolytic strategy, and safety questions.
Drug Metabolism & Supplement Interactions
Shared pharmacokinetic, transporter, supplement-interaction, and drug-exposure questions.

Immunotherapy Treatment

When researchers asked whether there were metabolic signals in the blood and gut that tell us who is more likely to benefit from immunotherapy, histidine stood out as one of the strongest signals.

What was learned

Higher baseline blood histidine was linked to longer progression-free survival and longer overall survival in several cohorts.
The gut microbiome mattered. In eubiosis, histidine tracked with more favourable response patterns. In dysbiosis, it was more often converted into metabolites such as imidazole propionate, which tracked with worse outcomes.
Mouse work suggested histidine may do more than mark response. It may also support CD8 T-cell fitness and help immunotherapy work better.

For the full summary, see Diet and Gut Health May Shape Immunotherapy Response.

Use this section when the main question is

why treatment may have stopped working
whether progression reflects tumour biology or drug exposure
how biomarkers or metabolism may change next steps
how dormancy, residual disease, or resistance escape may fit the picture
how therapy-induced senescence or senolytic follow-up may fit the picture
how supplement use, enzyme pathways, or metabolism may affect drug exposure

For symptom burden, side-effect interpretation, and recovery support, use the separate Side Effects Overview.

Some related pages sit beside this hub rather than inside it:

Current status

This hub now stands on its own.

More resistance pages can be added here without being mixed into side-effect navigation.

This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.