Redox Dual Action
Context-dependent polydatin redox activity explaining selective toxicity toward cancer cells while sparing normal tissues
ROS-Dependence: CONTEXT-DEPENDENT DUAL ACTION
Polydatin exhibits sophisticated redox modulation depending on cellular environment and metabolic state:
At lower doses or in normal cells:
Acts as an antioxidant, activating Nrf2/HO-1 antioxidant pathways, protecting normal tissues from oxidative damage. Enhances endogenous antioxidant defences by activating SOD and GSH-Px.
At higher doses in metabolically stressed tumour cells:
Functions as a pro-oxidant, generating excessive ROS through NOX5 activation and mitochondrial dysfunction. Cancer cells with pre-existing oxidative stress, high metabolic demands, or impaired antioxidant capacity are particularly vulnerable to this cytotoxic oxidative burst.
See References for Mechanisms of Action Page
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