Aug 7th 2020
This current version of the breast cancer pathways worksheet project has been a collaboration between Maria Bachteal and Abbey Mitchell. Please check the Change Log monthly for updates. The information in these documents came from literature searches of laboratory and clinical research. This information is not meant as medical advice. Please consult a medical practitioner before adding any drug or supplement to your protocol.
We offer deep gratitude and appreciation to Jane McLelland, whose best selling book titled How to Starve Cancer directed us to spend countless hours searching and organizing the current research specific to breast cancer pathways. Five of the pages in this worksheet are structured to reflect the “Five Hallmarks of Cancer,” concept as described by McLelland (2018). McLelland would like worksheet user to know that she has no connection to this breast cancer pathways worksheets project. She has her own Facebook group which we encourage you to join after you have read, or are reading her book. www.facebook.com/groups/off.label.drugsforcancer
The authors of this free worksheet project have been diagnosed with advanced breast cancer and have many friends with the diagnosis. These free-to-download worksheets were created to support our healing community, who clearly have an urgent need to access this information summarized in a way that they can quickly apply to their own healing journey.
The information presented is not meant as medical advice. Please consult a medical practitioner before adding any drug or supplement to your protocol.
Each page of the worksheets contains a list of pathways that the cancer cells can use to survive and a list of mostly off-label drugs and supplements which are sorted alphabetically, not by order of effectiveness. Because drugs are more targeted and bio-available, they are more likely to block a pathway. Herbs have more diverse action but may have problems with bio-availability when taken orally. They should be considered useful to down-regulate—or reduce the function of—a pathway but likely not to block it fully.
How many inhibitors (drugs, herbs, nutrients) should you take for each pathway? That depends on many factors. This is not meant to be a prescriptive document but rather a guide to help you see which supplements could inhibit which pathways according to research studies. Drugs are much more likely to be more complete inhibition agents than herbs, so many patients consider multiple herbs for a pathway. Keep in mind that many herbs are multi-taskers and affect many pathways for cancer. If the breast cancer is early-stage a patient might take a less aggressive approach than if it is later stage and actively growing. Totally up to the individual.
Not all breast cancers use all pathways. If you don’t have information on your tumor genetics, consult the short descriptions under each pathway title to see how your sub-type of breast cancer uses that particular pathway. We encourage users to seek out help from an integrative medical doctor or nutritionist who specializes in cancer to help you create the best protocol for your individual situation.
Has the pathway inhibition information been validated?
Most of the information summarized in the worksheets comes from pre-clinical research, meaning not verified in humans. Because of the lack of financial incentives, human research on off-label drugs and supplements is rare. We have consulted books, presentations, and textbooks published by naturopathic oncologists and other integrative cancer practitioners. These practitioners have each used some of these off-label drugs, supplements, and therapies within their comprehensive protocols, in a clinical setting, to improve the effectiveness of conventional treatments. The practitioners whose publications provided supporting information include, but are not limited to, the following (in no particular order): Neil McKinney, ND, Keith Block, MD, Daniel Thomas, M.D, Brian Lawenda, MD, Donnie Yance, MH, CN, RH (AHG), Lise Alschuler, ND, FABNO, Dwight McKee, MD, Gurdev Parmar, ND, FABNO, Jason Miller, DACM, LAc, Nalini Chilkov, OMD, LAc, Tina Kaczor, ND, FABNO, Kristin Wohlschlagel, RN and Nasha Winters, FABNO
What’s the point of this worksheet? Once you have downloaded and then completed a master data sheet in Google docs for your sub-type we imagine that you will be rewarded with some valuable insight into the way in which your choices are reflected in the current breast cancer research. Equally you may see more clearly where you might have gaps in your protocol worth discussing with your integrative practitioner. Either way, information is power. Our dream is to see this information we have gathered and ordered, available to everyone for free, in an easy to access online format.
Technical note: In this current version you will still have to “repeatedly” indicate that you take a drug or supplement when it appears for many different purposes across the worksheets for your breast cancer sub type.
Instructions to work with the current version in which you enter everything manually.
- Download the Google spreadsheet for your breast cancer sub-type.
Currently we have breast cancer pathway spreadsheets for these three breast cancer sub-types: ER+, HER2+ or TNBC . Click your sub-type (bold/left) to open that particular worksheet.
Triple positive breast cancer information is included within HER2+
- Once the spreadsheet has downloaded and been saved to your computer you have a couple of options:
a) open and edit the spreadsheet in your computer using Microsoft Excel.
b) upload the saved spreadsheet to Google sheets and then edit and or share the spreadsheet online. The advantages of the second option is that you can share the latest edit of your personal spreadsheet with anyone on your support team; anytime, anywhere. Google sheets is a free app accessible on a desktop and a mobile.
- What if I want to print my spreadsheet? Once downloaded and saved to your computer you can save each page as a .pdf and manually add page breaks within your print dialogue box.
- Where can I learn more about these pathways and the inhibitors?
a) this Facebook group: Breast Cancer Pathways. See photos>albums
b) within the private Facebook group: Healing Cancer Study Support Group and in that group’s photo library . Once a study group member it’s a good idea to bookmark and use the study group’s external A-Z directory of conversation threads and files to navigate your way to study topics of interest within this group space.
c) Pubmed and Google scholar will lead you to articles such as this one: Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells